Amyloidosis of Breast: An uncommon mimic of fat necrosis

Amyloidosis of Breast: An uncommon mimic of fat necrosis

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Breast amyloidosis is an uncommon diagnosis and may present as localized or systemic disease, the latter having associations with hematolymphoid neoplasms and, more rarely, autoimmune disease.Clinical presentation is Quad Canes variable and, as findings may mimic carcinoma, often leads to biopsy.Homogenous, eosinophilic amyloid deposits are perivascular, periglandular and/or stromal and may be misinterpreted as fibrosis or fibroadenomatoid change.

Coexistent organizing fat necrosis may be prominent and divert a pathologist from identifying the amyloid component.Work-up includes amyloid typing Power Supply and screening for systemic disease if there is no known related history.